Beagle 2: Seeking the signatures of life on Mars

ESA's Beagle 2 lander will land on Mars to search for signatures of present and past life. A Gas Analysis Package (GAP) with a mass spectrometer, XRF, Mossbauer, stereo cameras, microscope, environmental sensors, rock corer/grinder, and a Mole attachment are on the lander

Mass deworming programmes in middle childhood and adolescence

Soil-transmitted helminthes (STH) deworming programs remain among the largest public health programs in low- and lower-middle-income countries as measured by coverage. The actual scale of these programs remains unknown but substantial, with more than 1 billion donated doses of medicines effective against STHs delivered by formal programs and supplemented by widespread self-treatment and unprogrammed activities. STH infection declines worldwide likely reflect the influence of improved hygiene and sanitation associated with global declines in poverty, but it also reflects control efforts during the twentieth century that have largely eliminated STHs as a public health problem in previously endemic areas of North America (Mexico and the United States), Japan, Korea, and upper- middle-income countries throughout southern and eastern Asia. Much of the treatment targets delivery through schools and targets school-age children. STH infection associates with clinical and developmental outcomes that prove largely reversible by treatment. Both historical and contemporary trials of targeted treatment of infected individuals have also demonstrated benefit from treatment

The Prometheus Description Model: an examination of the taxonomic description-building process and its representation

A model for representing taxonomic descriptive data is presented. The model has been developed in response to the growing requirement for the global exchange of descriptive data. Meaningful exchange of data requires that data be represented in a form that can be consistently parsed and interpreted, requiring a common data model and the constrained and explicitly defined use of descriptive terms. The model presented here is divided into two parts that address both of these issues. A new data model for the representation and storage of taxonomic descriptive data is proposed that builds on and extends the best features of current descriptive data models and formats. An ontology-based model for defining and constraining the use of descriptive terms is also presented. The model is based on an analysis of current taxonomic working practices and the processes involved in generating a description. The model takes a specimen-oriented approach allowing descriptive data to be represented through a range of levels of abstraction from actual measurements of structures on a specimen to abstract descriptions of the features expected to be found on a specimen that is a member of a particular taxon. A comparison and discussion of the important aspects of the new model relative to existing models is presented

Mass Deworming Programs in Middle Childhood and Adolescence

The current debate on deworming presents an interesting public health paradox. Self-treatment for intestinal worm infection is among the most common self-administered public health interventions, and the delivery of donated drugs through mass drug administration (MDA) programs for soil-transmitted helminths (STHs) exceeds 1 billion doses annually. The clinical literature, especially the older historical work, shows significant impacts of intense STH infection on health; a burgeoning economics literature shows the long-run consequences for development (see, for example, chapter 29 in this volume, Ahuja and others 2017; Fitzpatrick and others 2017). Yet, the literature on clinical trials shows conflicting results, and the resulting controversy has been characterized as the worm wars. The two previous editions of Disease Control Priorities contain chapters on STH and deworming programs (Hotez and others 2006; Warren and others 1993). Much of the biological and clinical understanding reflected in those chapters remains largely unchanged. This chapter presents current estimates of the numbers infected and the disease burden attributable to STH infections to illuminate current program efforts, advances in the understanding of epidemiology and program design, and the controversy regarding the measurement of impact. Definitions of age groupings and age-specific terminology used in this volume can be found in chapter 1 (Bundy, de Silva, and others 2017)

A methodology for composing well-defined character descriptions.

Taxonomy has been described as “the science of documenting biodiversity”, which involves collecting, naming, describing, identifying and classifying specimens of organisms (Keogh, 1995). Descriptions are the fundamental information units used in the process of constructing classifications and communicating taxonomic concepts. The quality of stored description data is limited by the lack of a formal model and methodology for composing specimen descriptions, and by the absence of an agreed defined terminology. This impedes the communication, interpretation and reuse of original descriptions. This paper describes a novel approach to composing and recording taxonomic descriptions of botanical specimens. An underlying model for creating character descriptions is presented together with a process for creating an ontology of defined terms, which will be used to compose these description elements. It is hoped that these developments will facilitate the unambiguous interpretation of descriptions and enhance the taxonomic process

A methodology for composing well-defined character descriptions.

Taxonomy has been described as “the science of documenting biodiversity”, which involves collecting, naming, describing, identifying and classifying specimens of organisms (Keogh, 1995). Descriptions are the fundamental information units used in the process of constructing classifications and communicating taxonomic concepts. The quality of stored description data is limited by the lack of a formal model and methodology for composing specimen descriptions, and by the absence of an agreed defined terminology. This impedes the communication, interpretation and reuse of original descriptions. This paper describes a novel approach to composing and recording taxonomic descriptions of botanical specimens. An underlying model for creating character descriptions is presented together with a process for creating an ontology of defined terms, which will be used to compose these description elements. It is hoped that these developments will facilitate the unambiguous interpretation of descriptions and enhance the taxonomic process

Preoperative calculation of risk for prolonged intensive care unit stay following coronary artery bypass grafting

OBJECTIVE: Patients who have prolonged stay in intensive care unit (ICU) are associated with adverse outcomes. Such patients have cost implications and can lead to shortage of ICU beds. We aimed to develop a preoperative risk prediction tool for prolonged ICU stay following coronary artery surgery (CABG). METHODS: 5,186 patients who underwent CABG between 1st April 1997 and 31st March 2002 were analysed in a development dataset. Logistic regression was used with forward stepwise technique to identify preoperative risk factors for prolonged ICU stay; defined as patients staying longer than 3 days on ICU. Variables examined included presentation history, co-morbidities, catheter and demographic details. The use of cardiopulmonary bypass (CPB) was also recorded. The prediction tool was tested on validation dataset (1197 CABG patients between 1(st )April 2003 and 31(st )March 2004). The area under the receiver operating characteristic (ROC) curve was calculated to assess the performance of the prediction tool. RESULTS: 475(9.2%) patients had a prolonged ICU stay in the development dataset. Variables identified as risk factors for a prolonged ICU stay included renal dysfunction, unstable angina, poor ejection fraction, peripheral vascular disease, obesity, increasing age, smoking, diabetes, priority, hypercholesterolaemia, hypertension, and use of CPB. In the validation dataset, 8.1% patients had a prolonged ICU stay compared to 8.7% expected. The ROC curve for the development and validation datasets was 0.72 and 0.74 respectively. CONCLUSION: A prediction tool has been developed which is reliable and valid. The tool is being piloted at our institution to aid resource management